Endocrine Abstracts

Introduction: Pheochromocytomas and paragangliomas(PPGLs) are catecholamine-secreting tumors. Catecholamine excess contributes to bone resorption and secondary osteoporosis. PPGLs are treated surgically but limited data exists on the subsequent effect on bone status.Aim: To evaluate bone metabolism(BM) and bone mass density(BMD) before and after successful surgery of PPGLs.Methods: A retrospective study on (BM) of (PPGLs) patients ...

Introduction: The 2017 WHO Classification of Pituitary Tumors grades silent corticotroph adenomas (SCAs) as high-risk adenomas due to their aggressive clinical behaviour (high probability of recurrence). Nonetheless, studies comparing recurrence rates of SCA with other non-functioning pituitary adenomas (NFPAs) subtypes have provided conflicting results necessitating review of the evidence this recommendation relies on.Aims: To estimate recurrence rates ...

Introduction: Ganglioneuromas (GNs) are rare, benign tumors, arising from neural crest cells. Their incidence amongst adrenal masses is 0.3%-6%. The majority are incidentalomas and hormonally inactive but a subset may cause compressive effects. Presentation in the context of genetic syndromes (NF1/NF2, RET, MAX, Von Hippel Lindau disease) has been reported. We present two cases of adrenal GNs: Case 1. A 31-year-old female patient who presented with a history o...

Background: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes, and increased risk of post-natal type 2 diabetes and cardiovascular disease. However, whether GDM increases the risk of developing incident Non-alcoholic Fatty Liver Disease (NAFLD) is unclear and has not been well examined in previous studies. This is important considering the significant health burden of NAFLD and the opportunity to interfere in high risk population in order to red...

Background: In patients with adrenal nodules increased 17-OH Progesterone (17-OHP) does not necessarily indicate congenital adrenal hyperplasia (CAH) since adrenocortical tumors may harbor defects in steroidogenesis resulting in high steroid precursors, either basally or, usually, after Synacthen stimulation. Secretion of precursors has been associated with malignancy but it can also be present in benign adenomas.Case Presentation: A 62-year-old lady wit...